Ozone is a gas whose molecule consists of three atoms of oxygen, ozone for treatment is a blend of 5% ozone and 95% oxygen migraine migraine or migraine frequently manifested by headache located in the forehead pulsating character, sometimes radiating to the eyes and can be located to one side of the head, accompanied by of nausea or vomiting pain increases with light and noise is triggered by anxiety, insomnia and stress or by the intake of coffee, cheese or chocolate. It occurs in women aged 20-50 years; It can be that a notice with a decrease in visual acuity, sensation of tingling or even the decrease of strength in the arms and legs. There is a first phase with narrowing of the fine vessels in the membranes that cover the brain in migraine. In the second phase, there is a widening of the fine vessels. Proinflammatory substances (histamine and serotonin) that irritate nerve endings occur in the initial phase. At the level of brain mass in dilation, there is a decrease of the activity of nerve cells (hyper-polarization). BENEFITS of the ozone in the treatment of the MIGRAINE ozone is regenerative, anti-inflammatory and analgesic in migraine or migraine widening of the vessels thin, there was a decrease of watering of watering, of the oxygen and glucose, ozone facilitates transport and use both of the oxygen and glucose in the area suffer. The application of ozone rectal Insufflation of gas.