Monthly Archive: December 2013

Authenticity

It is truth, the Christmas can bring many good things. It is at this time that the people if find, in order to desire ones to the other votes of happiness, health and peace. It is at this time that the rich and poor families if find, so that the distances diminish. It is at this time where the climate of love and joy emerges, transforming dull faces into angelicais faces. It is at this time at last, where if it establishes, even so per one day or a night – the fraternity and the hope. The Christmas, in fact, makes things that until God it doubts. It has people, for example, that they never say ' ' good dia' ' , but in the day of Christmas they say not s ' ' good dia' ' as well as ' ' good tarde' ' , ' ' good noite' ' It has people that the entire year amuadas wake up, but in the day of Christmas, to the times, they are until boats of as much joy. It has people that they are incapable to give some cents somebody, but in the day of Christmas capable to give until the proper choir. It is the miracle of Christmas! But we can move thus? Or we are only, on this day, as well as in others, appearances, nothing more?

Attainment

These analogous ones normally are carried through way hemissintese from the triterpeno, being the modifications carried through in hidroxila in C-3 position and the acid carboxlico in C-17 position (Figure 5). An important hemisinttico.conhecido triterpeno as RPR 10361 (Figure 5), is a made up of low mass molar not peptdico capable to interact with gp 41 (LABROSSE et al, 2000), as well as stabilizing the complex gp120-gp 41 (LABROSSE et al, 1997), thus blocking the viral infection in inferior concentrations 10 nM.Seu esteroisomero, the IC9564 (Figure 5) is also powerful inhibitors fusing, capable to act in gp120 viral (HOLZ-SMITH et al, 2001) Had to the good results of the RPR103611 and IC 9564 (Figure 5) analogous ones of this composition have been synthecized. As example, we can cite the attainment of dihidro IC 9564 (Figure 6), that it is the chemical preparation saw hemissintese from the acid betulinico (SUN et al, 2003) that, after hidrogenao of the double linking, acetilao of hidroxila in C-3 position, in ascetic presence of anhydride and formation of acyl chloride in position in C-28 position, using itself chloride of oxalila, supplies the intermediary.

The coupling under basic conditions between intermediary 9. The coupling under basic conditions between intermediate 9 and 10 (HOLZ-SMITH et al, 2001), followed of the desproteo of the groups acetila and benzila in hidrxido presence of of sodium, supplies the white molecule, dihidro of sodium, supplies the white molecule, dihidro IC9564, 50 EC =0,4 M indicating the double linking of the isopropilideno group could not be important for the biological activity. However, its protected precursory intermediary presents a EC50> 28 M, what he indicates the importance of hidroxila (C-3) and of the acid carboxlico (C-28) he exempts for the biological activity.

Election

Had been analyzed 12 articles of different years, selecting? , in accordance with the respective item: age, civil state, color, level of escolaridade and socioeconmico, use of condom, partners and antecedents venereals disease. The too much articles and literary references had been basic in the development of the research, as half of complementation of the information. The development of this literary revision occurred from the stages: establishment of the objectives, definition of the exclusion criteria and inclusion; choice of the material to be I coat and studied, as well as the reading, it analyzes and interpretation of the same ones. From the inclusion criteria, women had been selected sexually active, with age and 15 and d 40 years. As exclusion criteria: men, sexually not active women with bigger age of 40 years.

After the election and organization of the data, had been developed graphical, with job of the statistics descriptive. The program Excel 2007, the express results in argued graphs was used as resource being on the optics of available literature. RESULTED the data the age, socioeconmico level, degree of escolaridade, color, civil state, partners, use of condom, and antecedents had been grouped in agreement venereals disease. For disposal of the results, it was necessary analysis of 12 articles. It had, therefore, selectivity of same how much the priority of each graph. In relation to the contributing factors the prevalence of gonorria was possible to identify that the age of 21-30 years corresponds 62.5% of carrying women of gonorria, while d15 years corresponds 12.5%, 31-40 12.5% and 16-20 also corresponds 12.5%.

Graph 1? Etria band of the carriers of Gonorria. (4,5,6,7,8,9,10,11) How much to the socioeconmico level gonorrheae in women of low level was detected 83.3% of women infectadas for the Neisseria, 16.7% average level, being unaware of incidence of the same one in people with high socioeconmico level. Graph 2? Distribution of the socioeconmico level affected by the Neisseria gonorrheae.

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